Россия
Россия
Россия
Россия
Ретиноевая кислота, производное витамина А, является важным компонентом сигнализации между клетками в организме. В то же время имеются противоречивые данные о ее влиянии на продолжительность жизни организма. В данной работе исследовано влияние ретиноевой кислоты на длительность жизни особей Drosophila melanogaster и их устойчивость к индуктору окислительного стресса параквату. Ретиноевая кислота в концентрациях 10 и 500 мкмоль/л оказала геропротекторный эффект на самок дрозофил, вызвав увеличение медианной продолжительности жизни и возраста 90 % смертности на 2–5 и 6 % соответственно. Но данное вещество не влияло на выживаемость самцов, так же как устойчивость к прооксиданту параквату особей обоих полов. Положительное действие ретиноевой кислоты на продолжительность жизни может быть обусловлено активацией генов репарации ДНК mei-9 и okr.
продолжительность жизни, стрессоустойчивость, ретиноевая кислота, Drosophila melanogaster
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